Publications by authors named "D J Bigelow"

Background: Vascular and bleeding complications remain a concern after transfemoral transcatheter aortic valve replacement (TAVR). The impact of the sheath type on these complications remains unclear.

Methods: The prospective MARVEL registry study analyzed enrolled 500 patients undergoing large-bore transfemoral procedures and arteriotomy closure with the MANTA vascular closure device from 10 hospitals in Europe and Canada.

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 Spontaneous temporal encephaloceles (STEs) are increasingly recognized as sequelae of idiopathic intracranial hypertension (IIH), which in turn may further complicate their management. We endeavored to review the University of Pennsylvania institutional experience on operative management of STEs, with a focus on factors which may influence surgical outcomes, particularly IIH.  Retrospective chart review over 9 years from 2013 to 2022.

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Article Synopsis
  • Study Purpose
  • : The research aimed to analyze the relationship between the monoclonal antibody teprotumumab and hearing loss, reviewing existing evidence about its ototoxic effects.
  • Data Review Process
  • : A systematic review included 7 studies focusing on 109 patients who received teprotumumab, while excluding non-relevant articles and those lacking comprehensive audiometric data.
  • Findings and Conclusion
  • : Ototoxicity was identified in 41% of patients, mainly affecting higher frequency hearing. Enhanced screening for hearing issues is suggested, but the exact occurrence rate is still unclear, highlighting the need for further research.
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Objective: Decisions around the diagnostic evaluation for pulsatile tinnitus (PT) remain challenging. We describe the usage patterns and diagnostic accuracy of imaging modalities and propose an evidence-based diagnostic approach for undifferentiated PT.

Study Design: Retrospective.

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Vestibular schwannomas (VS) are the most common tumor of the skull base with available treatment options that carry a risk of iatrogenic injury to the facial nerve, which can significantly impact patients' quality of life. As facial nerve outcomes remain challenging to prognosticate, we endeavored to utilize machine learning to decipher predictive factors relevant to facial nerve outcomes following microsurgical resection of VS. A database of patient-, tumor- and surgery-specific features was constructed via retrospective chart review of 242 consecutive patients who underwent microsurgical resection of VS over a 7-year study period.

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