IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion.

Many inflammatory stimuli can induce progenitor cells in the bone marrow to produce increased numbers of myeloid cells as part of the process of emergency myelopoiesis. These events are associated with innate training and can have long-term impacts on hematopoietic stem and progenitor cell (HSPC) development but can also compromise their function. While many cytokines support emergency myelopoiesis, less is known about the mechanisms that temper these events.

Mapping hazards to the global food system.

Environmental hazards associated with the global food system threaten societal integrity. Yet, there is a major data gap in the global understanding of how the prevalence of hazards is changing over time, how different classes of hazard are distributed, and whether the combined literature represents hazard prevalence equitably across research, policy and legislation, and news. Here, we explore this data gap, leveraging global research, policy, and news databases.

Freshwater Mussel (Unio pictorum) Shells Reveal Hydrological and Environmental Change From 1300 BC to the Present Day.

Preserved biological communities can provide baseline data about the historical ecosystems and environmental conditions that preceded recent anthropogenic alteration. Freshwater mussel shells show particularly good preservation, and the shell assemblages commonly found during archaeological excavations can offer insights into past ecosystems. We studied assemblages of Unio pictorum mussel shells from palaeochannel silts associated with the Late Bronze Age site of Must Farm in eastern England (c.