Publications by authors named "D Ivnitski"
Article Synopsis
- * Researchers are exploring how certain functional polymers emerged and became more prevalent from prebiotic mixtures without these complex systems.
- * The study highlights the importance of non-enzymatic replication in stabilizing and enriching specific peptide products through template-assisted reactions, offering insights into the molecular evolution that led to life as we know it today.
The Strong Influence of Structure Polymorphism on the Conductivity of Peptide Fibrils.
Angew Chem Int Ed Engl
August 2016
Article Synopsis
- Peptide fibril nanostructures show potential for use in future biotechnological and nanotechnological devices, with their effectiveness linked to well-defined architectures.
- Fibrils with aromatic group substitutions enhance electron delocalization, leading to varying conductivity based on their self-assembly conditions.
- The formation of specific polymorphs, governed by hydrogen bonding, electrostatic, and π-stacking interactions, allows for the optimization of conditions to achieve the polymorph with the best conductivity.
Article Synopsis
- Incorporating naphthalene diimide into short amphiphilic peptides leads to the creation of fibrils with strong intermolecular π-stacking interactions.
- These interactions can be adjusted independently of the overall structure of the fibrils.
- This research represents an initial advancement toward developing functional self-synthesizing materials.
Engineered enzyme conjugate of the small laccase enzyme from Streptomyces coelicolor and zinc finger DNA binding domain from Zif268 is demonstrated to bind double stranded DNA in a site specific manner while retaining enzymatic activity.
View Article and Find Full Text PDFThe redox potentials and reorganization energies of the type 1 (T1) Cu site in four multicopper oxidases were calculated by combining first principles density functional theory (QM) and QM/MM molecular dynamics (MD) simulations. The model enzymes selected included the laccase from Trametes versicolor, the laccase-like enzyme isolated from Bacillus subtilis, CueO required for copper homeostasis in Escherichia coli, and the small laccase (SLAC) from Streptomyces coelicolor. The results demonstrated good agreement with experimental data and provided insight into the parameters that influence the T1 redox potential.
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