[A relationship between clinical and biological disturbances in atherosclerotic lesions of the carotid arteries].

A study of the functional state of cerebral hemodynamics using transcranial dopplerography and blood excitotoxic amino acids, playing an important role in the pathogenesis of ischemic brain damage, has been carried out in 43 patients with atherosclerotic lesions of the carotid arteries. Neurological deficit that developed as a result of ischemic stroke was related to the changes of cerebral hemodynamics (a decrease of hemodynamic reserve and blood flow velocity in the middle cerebral artery) and an increase of the level of blood amino acids involved in excitotoxic mechanisms of the nerve tissue lesions in brain ischemia. These biochemical disturbances in the non-acute period of ischemic stroke may be explained by the state of chronic excitotoxicity that developed because of blood circulation insufficiency in the brain and a decrease of cerebrovascular reserve.

[The influence of coronary artery bypass graft surgery on cerebral hemodynamics].

The influence of coronary artery bypass graft surgery (CABGS) on cerebral hemodynamics is still understudied. At the same time, ischemic heart disease (IHD) is often comorbid to atherosclerotic carotid artery stenosis, with significantly higher risk of post CABGS cerebrovascular complications in patients with cerebral hemodynamics lesion. Indices of cerebral hemodynamic reserve have been studied in 40 patients with severe IHD before and after CABGS.

[Asymptomatic stenoses and thromboses of the carotid arteries: hemodynamic and ultrasound aspects].

The problem of asymptomatic stenoses of the internal carotid artery (ICA) has become a matter of great concern especially after ultrasonography of the great arteries of the head and, first of all, duplex scanning were introduced on a wide-scale basis into practice of the physicians of varying specialties. The growing population of patients with asymptomatic stenoses raises the problem of their further management with the purpose of preventing ischemic stroke. In connection with significant advances in vascular surgery carotid endarterectomy (CEE) has assumed an increasing role in the treatment of carotid stenoses.