[SAGA complex: the role in viability and development].

SAGA is a histone acetyltransferase complex, that cotranscriptionally performs histone modifications and is implicated in regulation of gene expression at the level of changes in chromatin structure. SAGA is also involved in mRNP biogenesis and export. In this review, we examined a contribution of SAGA and its subunits in the development.

[The role of multifunctional coactivator complex saga in regulation of eukaryotic gene expression].

Eukaryotic gene expression is known as a multistep process of high complexity. Transcription is one of cardinal and tightly regulated phase during gene expression. To provide accurate and precise work of gene regulation apparatus including a plethora of modification of chromatin structure and nucleosome dynamic turnover must be occurred.

[Functioning of macromolecular complexes at successive stages of gene expression as self-coordinated molecular machines].

The results of systemic investigations devoted to the role of the proteins SAYP and ENY2 from Drosophila melanogaster in the regulation of different stages of gene expression are presented. The gene expression is a system of multistage processes involving the preparation of the chromatin matrix, initiation of transcription, mRNA synthesis, as well as the formation of mPNR particles, their export, and translation in the cytoplasm. At each of these stages, a great number of factors present6ed usually by protein complexes consisting of different subunits work.

[Multifunctional factor ENY2 integrates the various stages of gene expression].

The ENY2/Sus1 is a multifunctional transcription factor which couples transcription with mRNA export. It is the component of the SAGA/TFTC and TREX-2/AMEX protein complexes. Recently, we described the interaction of ENY2 with one more protein complex, THO.