Dermatoses in adolescents of color.

In this article, we delineate some of the unique features of dermatoses in adolescents of color. The information provided should help assist practitioners in making accurate and timely diagnoses so that appropriate therapies can be prescribed.

Discrimination of gamma-hydroxybutyrate and ethanol administered separately and as a mixture in rats.

The physiological effects of gamma-hydroxybutyrate (GHB) are complex and not yet clearly defined. GHB has been labeled as a recreational drug and is reported to be frequently coabused with ethanol (ETH). Other studies have yielded discrepant results as to the interaction between GHB and ETH.

mu-, delta- and kappa-opioid receptor agonists do not alter the discriminative stimulus effects of cocaine or d-amphetamine in rats.

Opioid receptor agonists can modulate the activity of dopamine neurons and could therefore, modify the behavioral effects of drugs that act through the dopamine systems, such as d-amphetamine and cocaine. We tested the ability of agonists selective for the mu- (morphine, methadone, buprenorphine, nalbuphine and heroin), delta-(DPDPE and SCH32615), and kappa- (U69593 and bremazocine) opioid receptors to alter the discriminative stimulus effects of d-amphetamine and cocaine in rats. Separate groups of male Sprague-Dawley rats were trained to discriminate between 1.

The effects of opioid receptor antagonism on the discriminative stimulus effects of cocaine and d-amphetamine in the rat.

There is evidence that suggests that endogenous opioids can modulate brain dopamine systems and the behavioral effects of drugs that are mediated by those systems. The aim of this study was to examine the role of endogenous opioids in the discriminative stimulus effects of d-amphetamine and cocaine, through the use of receptor antagonists. Two separate groups of rats were trained to discriminate 1.

Rat strain differences in the potentiation of morphine-induced analgesia by stress.

Restraint stress has been shown to increase the magnitude and duration of morphine-induced analgesia; however, this phenomenon has only been investigated using the Sprague-Dawley rat strain. The purpose of this study was to determine if other rat strains would also exhibit a potentiated analgesic response to morphine compared to their unrestrained controls. Dose-response and time course curves for the analgesic effect of morphine (1.