Publications by authors named "D I Vodolazhskiĭ"

The study was designed to analyse the relationship between EGFR mutation and clinico-pathological features of lung adenocarcinoma in residents of southern Russia taking account oftheir age and sex, localization of the primary tumour, its cell differentiation, regional metastases, stage of disease and smoking status of the patients with mutant and wild-type EGFR genes. The frequency analysis included 29 somatic mutations in EGFR exones 18-21. The study revealed statistically significant associations of EGFR gene mutations with gender, smoking and stage of disease.

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Using karyological, allozyme, and molecular genetic analysis, habitation of the four Sylvaemus wood mice species, pygmy wood mouse (S. uralensis), wood mouse (S. sylvaticus), yellow-necked mouse (S.

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mtDNA D-loop is a non-coding locus actively used as an individualizing marker in molecular genetic research. Uneven distribution of SNP in D-loop suggests about irregular functional load within this region. The structural-functional role of various sites in D-loop of single individual's mtDNA and the degree of its (functional) importance from the point of phylogenetic conservatism are considered based on the analysis of nucleotide sequences.

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Polymorphism of mDNA D-loop central region (CR), positions 16366-0072) was studied versus hypervariable sections (HVS1), positions 16024-16365, and HVS2, positions 00073-00340, for a sample of 71 residents of the Russian Federation. Ten polymorphic positions with 56 nucleotide substitutions, 55 of which are transitions, were detect in the CR section; no insertions or deletions were found there. It was proven as possible to use the mDNA CR locus as an additional identification marker in the forensic-expert of the mDNA control region.

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An experimental study is described, which deals with polymorphism of nucleotide sequences of three structural genes of mitochondrial genome, i.e. of the 3d, small 4th, and 6th subunits of the NADN dehydrogenase complex (ND3, ND4L and ND6) sampled from Russian population.

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