[Metabolism and catabolism to CO2 of [14C] gamma-aminobutyric acid conjugates with pyridoxal phosphate, nicotinate and biotin].

Pharmacokinetics and catabolism to CO2 in the mice organism and metabolic transformation by the tissues homogenates of [1-14C] GABA and its conjugates with nicotinate, pyridoxal phosphate and biotin have been studied. The permeability of nicotinoyl-GABA through the hemato-encephalic barrier was 10 times as much as the corresponding value for GABA and its conjugates with other vitamins. PLP-GABA is eliminated more rapidly from the brain in comparison with GABA, biotinyl-GABA is retained to a higher degree in kidneys, the entero-hepatic recycling takes place more actively for nicotinoyl-GABA.

[Qualitative and quantitative evaluation of the information flow regarding the "medical insurance" problems].

The presented qualimetric evaluation of documentary information flow permitted one to identify some of its characteristics, single out a group of nuclear and perinuclear journals containing about 70 percent of the entire documentary flow publications on the given problem and provide recommendations on the organization and retrieval search in the reference-information fund of our country.

[Effect of thiamine and its derivatives on acetylcholinesterase activity of the blood and brain of albino mice].

Thiamine, thiaminepyrophosphate and 4-methyl-5-beta-oxyethylthiazole are studied for their effect on the acetylcholinesterase activity in the brain, blood plasma and cells. The activity of acetylcholinesterase in blood cells is shown to be inhibited most of all by thiamine and thiazole. Acetylcholinesterase of the brain has been efficiently inhibited only by thiamine pyrophosphate.