Publications by authors named "D I Sherman"
Purpose: Reduced force control after anterior cruciate ligament (ACL) injury and reconstruction may contribute to poor function. Various metrics (linear and nonlinear) have been employed to quantify force control. The aims of this review were to synthesize evidence assessing knee extensor and flexor force control after ACL injury (ACLD) or reconstruction (ACLR) and to investigate the potential effects of injury management (e.
View Article and Find Full Text PDFThe Winam Gulf in the Kenyan region of Lake Victoria experiences prolific, year-round cyanobacterial harmful algal blooms (cyanoHABs) which pose threats to human, livestock, and ecosystem health. To our knowledge, there is limited molecular research on the gulf's cyanoHABs, and thus, the strategies employed for survival and proliferation by toxigenic cyanobacteria in this region remain largely unexplored. Here, we used metagenomics to analyze the Winam Gulf's cyanobacterial composition, function, and biosynthetic potential.
View Article and Find Full Text PDFThe privileged fused-ring system comprising the bicyclo[2.2.2]diazaoctane (BDO) core is prevalent in diketopiperazine (DKP) natural products with potent and diverse biological activities, with some being explored as drug candidates.
View Article and Find Full Text PDFArticle Synopsis
- - M2D2 is a two-stage machine learning pipeline that helps discover effective antimicrobial drug combinations, aiming to tackle drug resistance without the need for costly omics data.
- - It enhances the accuracy of identifying drug targets by using both experimental and computational methods, and provides insights into how different drugs interact with each other.
- - The framework was validated with experiments involving 946 combinations of approved drugs and antibiotics, revealing promising synergies, including a notable combination of a cerebrovascular drug and penicillin, while also confirming these findings through genome-wide CRISPR screens.
Background: Increasingly, patient satisfaction scores are being used to assess emergency physicians. We sought to determine whether the patient satisfaction scores collected by our hospital system are lower for patients who are treated in the emergency department (ED) on night shifts as compared to those treated on day shifts.
Methods: We performed a cross-sectional analysis of patient satisfaction scores from three EDs in Florida.