Publications by authors named "D I Savenkova"
Article Synopsis
- Researchers aimed to develop a cellular model to study the effects of tumor necrosis factor (TNF) depending on the presence or absence of TNFR1 and TNFR2 receptors in cell lines.
- They created TNFR1 knockout versions of ZR-75/1 and K-562 cell lines to analyze how this absence affects receptor distribution, cell cycle, cell death, and gene expression in response to TNF.
- Findings showed that removing TNFR1 led to changes in TNFR2 distribution, influencing sensitivity to TNF and altering cell proliferation and death patterns in different ways across the two cell lines.
Article Synopsis
- TNF-α is a cytokine involved in immune response and inflammation and is activated during influenza A virus infections, leading to increased production of other cytokines.
- Researchers created a knockout mouse strain lacking TNF-α, which showed more viral genomes but similar amounts of live virus compared to normal mice.
- The modified mice had less lung inflammation, suggesting this model can help further investigate the effects of viral infections on pathology.
Article Synopsis
- * While effective, viral vectors can trigger immune responses and disrupt cell metabolism, leading to potential side effects that need careful evaluation.
- * The review discusses how the entry of viral vectors and the delivery of non-coding RNAs can influence miRNA signaling pathways, which are crucial for gene expression regulation.
Bacillus velezensis Krd-20 strain with antifungal activity was isolated from the wheat rhizosphere. This strain is used to suppress fungi of the Fusarium sp. when growing oyster mushroom (Pleurotus ostreatus).
View Article and Find Full Text PDFNaPi2b is a sodium-dependent phosphate transporter that belongs to the SLC34 family of transporters which is mainly responsible for phosphate homeostasis in humans. Although NaPi2b is widely expressed in normal tissues, its overexpression has been demonstrated in ovarian, lung, and other cancers. A valuable set of antibodies, including L2 (20/3) and MX35, and its humanized versions react strongly with an antigen on the surface of ovarian and other carcinoma cells.
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