Diastereoselective Anomeric C(sp)-H Cyclization Towards the Design of New Cyclophane-Braced Glycopeptides.

Here we report a macrocyclization route towards the synthesis of glycophane peptides by a selective C-H arylation of the anomeric bond. This approach demonstrates the power of Pd-catalysis C-H activation to access unusual cyclic peptides.

Synthesis of 3,3-Spirocyclic 2-Phosphonoindolines via a Dearomative Addition of Phosphonyl Radicals to Indoles.

The diastereoselective synthesis of α-amino phosphonate derivatives embedded in spirocyclic indolines is reported. The present method proceeds via the dearomative addition of phosphonyl radicals at the C2-position of the indole nucleus in oxidative conditions followed by the intramolecular trapping of the resulting carbocation before rearomatization. trans-3,3-Spirocyclic 2-phosphonoindolines were thus obtained.

Radical-Mediated Dearomatization of Indoles with Sulfinate Reagents for the Synthesis of Fluorinated Spirocyclic Indolines.

The dearomative introduction of trifluoromethyl and 1,1-difluoroethyl radicals, generated from their corresponding sulfinate salts, into the C2 position of indole derivatives allows the diastereoselective synthesis of three-dimensional 3,3-spirocyclic indolines over C-H functionalized indoles.

[Environmental factors and male infertility in industrial cities].

Unfavourable environmental factors of industry in the cities can cause changes in male reproductive system leading to infertility. The majority of chemical substances revealed in the atmosphere and in the ground of cities and regions are reprotoxicants with damaging effects on different stages of germinal cells maturation. Besides the environmental factors some occupational pollutants can have gonadotropic activity and also result in the disturbances of spermatogenesis.

[Clinical, pathophysiological and morphological features of closed craniocerebral trauma in combatants].

We studied clinicodynamic features of neuropsychic disorders resultant from a combat craniocerebral trauma (CCT) in patients of Nizhny Novgorod Regional Neurological Hospital for War Veterans (n = 420). The patients were divided into three groups: with mild, moderate and severe traumas. All the patients were examined clinically and clinicophysiologically (electroencephalography, computer tomography, electrocardiography, ultrasound and X-ray investigations).