[The efficacy of intravenous lacosamide in psychiatric hospital].

Objective: To evaluate the efficacy and tolerability of intravenous lacosamide (vimpat) in inpatients with frequent partial-onset seizures and affective and cognitive disorders.

Material And Methods: Fifteen patients were enrolled including 14 patients diagnosed with «organic personality disorder associated with epilepsy» (cryptogenic or symptomatic epilepsy with frequent partial-onset and/or secondary-generalized seizures (serial seizures in some cases) and 1 patient with a preliminary diagnosis of «organic schizophrenia-like disorder», which was changed for «organic personality disorder associated with epilepsy» after examination. Patients were treated with 2--3 antiepileptic drugs (AEDs), but no one of them received earlier lacosamide.

[Evaluating adaptogenic properties of Rhodiola rosea extract in human mononuclear cell culture and rat tissues].

The administration of various doses of Rhodiola rosea roots and rhizome spissum with known concentrations of salidroside, n-tyrosol, and rosavine leads to an increase in stress proteins 70 content in human mononuclear cell culture and in tissues of Wistar rats. A one-week peroral administration of Rh. Rosea preparation increases the content of constitutive Hsc70 in liver and the amount of hepatocytes with low succinate dehydrogenase activity.