Publications by authors named "D I Kingsley"
Article Synopsis
- The study investigates the genetic basis of axial pattern variations in wild fourspine sticklebacks in Nova Scotia, focusing on traits like dorsal spine structure and vertebra counts.
- Using genetic crosses and quantitative trait locus (QTL) mapping, the research identifies a significant QTL on chromosome 6 that explains 15%-30% of variations in dorsal spine traits, suggesting a strong genetic influence on these morphological features.
- It concludes that regulatory changes in developmental gene clusters are a common mechanism behind major morphological changes in different stickleback species.
Article Synopsis
- The threespine stickleback iridovirus (TSIV) is identified as a double-stranded DNA virus and the first of its kind found in North American wild fish, with a new occurrence reported in sticklebacks from Stormy Lake, Alaska.
- Researchers assembled a nearly complete 115-kilobase genome of TSIV, revealing 94 open reading frames (ORFs), mostly similar to other iridoviruses, and some likely acquired through lateral gene transfer.
- A significant prevalence of TSIV was observed in sticklebacks prior to a rotenone treatment aimed at controlling invasive fish, with a complete absence of the virus found in the population two years later, indicating a strong association between the treatment and the
Ethnomedicinal breakthroughs in snake bite therapy: From folklore to forefront.
Toxicol Rep
December 2024
Article Synopsis
- Snakebite envenomation is a major health issue, particularly in tropical areas like India, causing serious injury and death.
- The review examines how ethnomedicinal herbs can complement traditional antivenoms, which are often expensive and have availability issues.
- It also highlights the importance of understanding different snake venoms and the potential of using bioinformatics to enhance antivenom research, merging traditional remedies with modern science for better treatment options.
Piezo1 is a mechanosensitive, nonselective Ca2+ channel which is broadly expressed in CD4+ T cells. Using lineage-specific Piezo1 knockout mice (Piezo1cKO), we show that loss of Piezo1 in CD4+ T cells significantly increased IFNγ and IL-17 production in vitro under TH1 and TH17 polarizing conditions, respectively. Despite their intrinsic proinflammatory phenotype, Piezo1cKO T cells are incapable of establishing disease in vivo in three separate adoptive transfer (AT) T cell-mediated inflammatory mouse models, including experimental autoimmune encephalomyelitis, inflammatory bowel disease (IBD), and graft versus-host disease.
View Article and Find Full Text PDFA critical question in biology is how new traits evolve, but studying this in wild animals remains challenging. Here, we probe the genetic basis of trait gain in sea robin fish, which have evolved specialized leg-like appendages for locomotion and digging along the ocean floor. We use genome sequencing, transcriptional profiling, and interspecific hybrid analysis to explore the molecular and developmental basis of leg formation.
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