Publications by authors named "D I Jodrell"
Immunotherapy advances have been hindered by difficulties in tracking the behaviors of lymphocytes after antigen signaling. Here, we assessed the behavior of T cells active within tumors through the development of the antigen receptor signaling reporter (AgRSR) mouse, fate-mapping lymphocytes responding to antigens at specific times and locations. Contrary to reports describing the ready egress of T cells out of the tumor, we find that intratumoral antigen signaling traps CD8 T cells in the tumor.
View Article and Find Full Text PDFArticle Synopsis
- Scientists found out that a substance called adenosine helps certain pancreatic cancer cells avoid being attacked by the immune system, making it harder to treat the cancer with immunotherapy.
- They used special tests on mice with pancreatic cancer to study how this adenosine affects the environment around the tumor and how immune cells behave there.
- The researchers discovered that blocking adenosine can slow down tumor growth and make other cancer treatments work better by changing how immune cells are present in the tumor area.
Article Synopsis
- Chemotherapy for metastatic pancreatic adenocarcinoma has limited effectiveness, and there's a need for reliable biomarkers to predict patient outcomes.
- In a study of 146 patients, factors like poor performance status, liver metastases, and detectable KRAS ctDNA were linked to worse overall survival, while a drop in albumin levels at 4 weeks was particularly indicative of poorer outcomes.
- The findings suggest that easily measurable patient factors can help predict chemotherapy success, but the utility of KRAS ctDNA requires more research.
Article Synopsis
- Nanocarriers are emerging as a promising method for drug delivery, but transitioning from lab to clinical use is still challenging due to various factors.
- This work focuses on creating new immunocompatible polymer nanocarriers using melanin-mimetic polydopamine and Pluronic F127, made under mild and reproducible conditions to ensure consistent particle sizes.
- Studies show that these nanocarriers effectively deliver the drug irinotecan's active metabolite SN38, leading to increased anti-cancer effects against pancreatic cancer cells, highlighting their potential in improving treatment outcomes for this tough-to-treat disease.
An elevated neutrophil-lymphocyte ratio negatively predicts the outcome of patients with cancer and is associated with cachexia, the terminal wasting syndrome. Here, using murine model systems of colorectal and pancreatic cancer we show that neutrophilia in the circulation and multiple organs, accompanied by extramedullary hematopoiesis, is an early event during cancer progression. Transcriptomic and metabolic assessment reveals that neutrophils in tumor-bearing animals utilize aerobic glycolysis, similar to cancer cells.
View Article and Find Full Text PDF