Publications by authors named "D I I Greere"
Introduction: The Fat Mass and Obesity-Associated () gene encodes a demethylase, which modulates RNA N6-methyladenosine (m6A) and plays a regulatory role in adipocyte differentiation and the pathogenesis of human obesity.
Methods: To understand the potential role of in osteoporosis (OP), we investigated five single nucleotide variations (SNVs) in intron 1 (rs8057044, rs8050136, rs9939609, rs62033406, and rs9930506) of the gene, and a missense SNV i.e.
Article Synopsis
- - Osteoporosis (OP) affects about 30% of postmenopausal women and is often linked to metabolic syndrome (MetS), which has a controversial impact on bone health.
- - A study involving 188 patients assessed bone mineral density (BMD), insulin resistance, and muscular strength, revealing that both normal BMD/osteopenia and OP patients exhibited varying prevalence of MetS without significant differences in insulin resistance.
- - Findings indicate that insulin resistance negatively affects OP patients, and the relationship between MetS and bone health shifts depending on body mass index (BMI), emphasizing the importance of considering obesity levels when analyzing OP in postmenopausal women.
INSULIN RESISTANCE AND PATHOGENESIS OF POSTMENOPAUSAL OSTEOPOROSIS.
Acta Endocrinol (Buchar)
February 2024
Osteoporosis (OP) is a disease predisposing postmenopausal women to fractures, and often accompanied by insulin resistance (IR) and metabolic syndrome (MetS). Previous studies provided contradictory results concerning prevalence of MetS in postmenopausal OP. To better understand the pathogenesis of IR, we reviewed cellular and molecular aspects and systematically reviewed studies providing homeostasis model assessment (HOMA) index.
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