Publications by authors named "D I Gabrilovich"

Extracellular vesicles (EVs) are associated with intercellular communications, immune responses, viral pathogenicity, cardiovascular diseases, neurological disorders, and cancer progression. EVs deliver proteins, metabolites, and nucleic acids into recipient cells to effectively alter their physiological and biological response. During their transportation from the donor to the recipient cell EVs face differential ionic concentrations, which can be detrimental to their integrity and impact their cargo content.

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Neutrophils have a pivotal role in safeguarding the host against pathogens and facilitating tissue remodeling. They possess a large array of tools essential for executing these functions. Neutrophils have a critical role in cancer, where they are largely associated with negative clinical outcome and resistance to therapy.

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The microenvironment plays an important role in promoting tumor cell chemoresistance, but the mechanisms responsible for this effect are not clear. Here, using models of multiple myeloma (MM) and solid cancers, we demonstrate a novel mechanism mediated by neutrophils, a major cell population in the bone marrow (BM), that protects cancer cells from chemotherapeutics. We show that in response to tumor-derived soluble factors, BM neutrophils release their DNA in the form of neutrophil extracellular traps (NETs).

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Article Synopsis
  • - Macroautophagy is a complex process that can lead to cell death, influenced by various cell types and stressors, while ferroptosis is a specific kind of cell death related to lipid damage and iron dependency.
  • - Certain types of autophagy, like ferritinophagy and lipophagy, play a role in triggering ferroptotic cell death by degrading protective proteins, whereas others, such as reticulophagy, help protect cells from this damage.
  • - The review seeks to clarify the relationship between autophagy and ferroptosis, focusing on defining terms, outlining key components, discussing experimental techniques, and providing interpretation guidelines for ongoing research.
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