Enhanced mitochondrial function and delivery from adipose-derived stem cell spheres via the EZH2-H3K27me3-PPARγ pathway for advanced therapy.

Background: Microenvironmental alterations induce significant genetic and epigenetic changes in stem cells. Mitochondria, essential for regenerative capabilities, provide the necessary energy for stem cell function. However, the specific roles of histone modifications and mitochondrial dynamics in human adipose-derived stem cells (ASCs) during morphological transformations remain poorly understood.

Patient and healthcare provider perspectives on treatment patterns and patient satisfaction of seborrheic dermatitis in the United States.

Introduction: Seborrheic dermatitis (SD) affects a large, diverse population and is associated with significant morbidity/burden.

Methods: The Harris Poll conducted online surveys to understand the perceptions, preferences, and experiences regarding treatments of US patients with SD and dermatology healthcare providers (HCPs) from December 2021 to January 2022.

Results: In this survey, patients using SD treatment invested on average 34 min/d treating SD with 5.

Leukocytosis Associated With Medroxyprogesterone in Gender-Affirming and Fertility Treatments.

Leukocytosis, defined as an elevated white blood cell (WBC) count, can arise from physiological, infectious, neoplastic, or medication-related causes. While leukocytosis has been well-documented in conditions such as infections and malignancies, drug-induced leukocytosis is relatively rare, particularly in individuals undergoing gender transition therapies. Medroxyprogesterone, a progestin used in both fertility treatments and gender-affirming care, has been associated with hematologic changes, though its role in sustained leukocytosis remains underexplored.

External validation of the German Registry for Acute Aortic Dissection Type A score in patients undergoing surgery for acute type A aortic dissection.

Objective: Surgery for acute type A aortic dissection carries a high risk of morbidity and mortality compared with routine cardiac surgical procedures. The German Registry for Acute Aortic Dissection Type A score has been recommended for use as a mortality risk-stratification tool in recent guidelines. We sought to externally validate this score in our local population.

Chicken anemia virus inhibits hematopoiesis and development of chicken embryo.

Chicken anemia virus (CAV), when primarily transmitted through the vertical route, could result in a significant global prevalence. Specifically, vertical CAV transmission, especially in newly-hatched chicks, may cause anemia and immunosuppression, leading to significant losses in the global poultry industry. Although CAV infection of chick embryos is critical in its vertical transmission, the pathogenicity of CAV in these embryos remains unclear.