Drug repurposing for COVID-19 via knowledge graph completion.

Objective: To discover candidate drugs to repurpose for COVID-19 using literature-derived knowledge and knowledge graph completion methods.

Methods: We propose a novel, integrative, and neural network-based literature-based discovery (LBD) approach to identify drug candidates from PubMed and other COVID-19-focused research literature. Our approach relies on semantic triples extracted using SemRep (via SemMedDB).

Drug Repurposing for COVID-19 via Knowledge Graph Completion.

Objective: To discover candidate drugs to repurpose for COVID-19 using literature-derived knowledge and knowledge graph completion methods.

Methods: We propose a novel, integrative, and neural network-based literature-based discovery (LBD) approach to identify drug candidates from both PubMed and COVID-19-focused research literature. Our approach relies on semantic triples extracted using SemRep (via SemMedDB).

Disentangling the evolution of MEDLINE bibliographic database: A complex network perspective.

Scientific knowledge constitutes a complex system that has recently been the topic of in-depth analysis. Empirical evidence reveals that little is known about the dynamic aspects of human knowledge. Precise dissection of the expansion of scientific knowledge could help us to better understand the evolutionary dynamics of science.

Telegenetics: an Update on Availability and Use of Telemedicine in Clinical Genetics Service.

Although telegenetics as a telehealth tool for online genetic counseling was primarily initiated to improve access to genetics care in remote areas, the increasing demand for genetic services with personalized genomic medicine, shortage of clinical geneticists, and the expertise of established genetic centers make telegenetics an attractive alternative to traditional in-person genetic counseling. We review the scope of current telegenetics practice, user experience of patients and clinicians, quality of care in comparison to traditional counseling, and the advantages and disadvantages of information and communication technology in telegenetics. We found that live videoconference consultations are generally well accepted by both clients and clinicians, and these have been successfully used in several genetic counseling settings in practice.

Link Prediction on a Network of Co-occurring MeSH Terms: Towards Literature-based Discovery.

Objectives: Literature-based discovery (LBD) is a text mining methodology for automatically generating research hypotheses from existing knowledge. We mimic the process of LBD as a classification problem on a graph of MeSH terms. We employ unsupervised and supervised link prediction methods for predicting previously unknown connections between biomedical concepts.