Publications by authors named "D Horvat"

Background: The treatment of status epilepticus (SE) in children with cardiac disease is challenging given their often-tenuous hemodynamic state. We aim to determine whether ketamine is safe and effective in children with cardiac disease as the first-line continuous infusion for the treatment of refractory SE (RSE) and to compare ketamine to midazolam for the treatment of RSE in this population.

Methods: This is a single-center retrospective cohort study of pediatric patients with cardiac disease and RSE admitted to the cardiac intensive care unit at a tertiary children's hospital between January 1, 2017 and June 30, 2023.

View Article and Find Full Text PDF

Objective: To describe electroencephalographic (EEG) changes in pediatric patients with cerebral edema after cardiac arrest.

Methods: A retrospective study of patients admitted to the pediatric intensive care unit from July 2021 to January 2023. We included patients with cardiac arrest and changes in EEG background with clinical changes and/or neuroimaging consistent with cerebral edema.

View Article and Find Full Text PDF

The ever-increasing life expectancy of the global population introduces a critical perspective on the impact of aging as an immutable cardiovascular risk factor, particularly manifesting in the alterations observed in the pulmonary artery (PA). Mechanisms contributing to aging-induced changes in PA include endothelial dysfunction, chronic inflammation, and structural changes in the arterial wall over time. These alterations extend beyond mere elasticity, exerting profound effects on pulmonary hemodynamics.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to assess complications and mortality related to vagus nerve stimulation (VNS) used for drug-resistant epilepsy treatment.
  • A total of 117 VNS procedures were analyzed over 23 years, revealing common early complications like hoarseness and cough, while fewer severe complications were noted, particularly among children with intellectual disabilities.
  • Despite some risks and late complications, VNS therapy appears mostly safe for long-term use, with a suggestion that it may reduce the incidence of sudden unexpected death in epilepsy (SUDEP) over time.*
View Article and Find Full Text PDF

A 13-day-old, late preterm male, born appropriate for gestational age, presented to the pediatric clinic for his routine 2-week well visit with less than 1-day history of decreased oral intake and lethargy. During the baby's well exam, he acutely decompensated and required resuscitation and transfer to the emergency department, where he was intubated for frequent apneic events. He was admitted to the NICU for management and further workup.

View Article and Find Full Text PDF