Neonates have different cellular composition in their bronchoalveolar lavage fluid (BALF) when compared to foals and adult horses; however, little is known about the non-cellular components of BALF. The objective of this study was to determine the proteomic composition of BALF in neonatal horses and to compare it to that of foals and adult horses. Bronchoalveolar lavage fluid samples of seven neonates (< 1 week age), four 5 to 7-week-old foals, and six adult horses were collected.
View Article and Find Full Text PDFBackground: Intra-articular (IA) corticosteroids are regularly used in equine athletes for the control of joint inflammation.
Objectives: The goal of this study was to use an acute synovitis inflammation model to determine the residual effects of IA betamethasone and triamcinolone acetonide on various inflammatory parameters and lameness.
Study Design: Crossover randomised trial.
Background: Foals that develop pulmonary ultrasonographic lesions on Rhodococcus equi (R. equi) endemic farms are treated with antibiotics because those at risk of developing clinical pneumonia (~20%) cannot be recognised early. Candidate biomarkers identified using metabolomics may aid targeted treatment strategies against R.
View Article and Find Full Text PDFObjective: To perform lipidomic analysis of surfactant and plasma from asthmatic and healthy horses.
Animals: 30 horses with clinical signs of asthma and 30 age-matched control horses.
Procedures: Detailed history, physical examination, CBC, and bronchoalveolar lavage fluid (BALF) cytologies were obtained.