Publications by authors named "D Horgan"
Article Synopsis
- Personalized medicine in oncology has great potential, but its adoption in Europe is hindered by various challenges, as seen with the Oncotype DX Breast Recurrence Score assay.
- The case study details obstacles faced in integrating this genomic test into European healthcare from 2004 to 2018, including issues with clinical evidence, reimbursement, and regulatory processes.
- Key findings from the TAILORx study suggest that, for certain breast cancer patients, endocrine therapy may suffice without the need for additional adjuvant chemotherapy, highlighting the importance of personalized treatment approaches.
Background: A comparison of the operations of Clinical Cancer Centers and Comprehensive Cancer Centers across Europe provides novel data on the interrelation between different factors in care delivery.
Method: The analysis is based on a survey of key dimensions in care delivery, comparing routine treatment, advanced technology integration, research participation, and innovation adoption across the two types of centers.
Results: Clinical Cancer Centers excel in providing routine cancer treatment through multidisciplinary teams but struggle with advanced technology integration and research participation.
This manuscript delineates the pathway from in-house research on Artificial Intelligence (AI) to the development of a medical device, addressing critical phases including conceptualization, development, validation, and regulatory compliance. Key stages in the transformation process involve identifying clinical needs, data management, model training, and rigorous validation to ensure AI models are both robust and clinically relevant. Continuous post-deployment surveillance is essential to maintain performance and adapt to changes in clinical practice.
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- - PIONEER is a European initiative that combines the efforts of 34 organizations across 9 countries to enhance prostate cancer screening, diagnosis, and treatment using big data analytics.
- - The project has created a comprehensive platform that integrates various data sources, helping to respond to critical research questions and improve understanding of prostate cancer management at different stages.
- - Despite successes, challenges with real-world data persist, necessitating ongoing collaboration and knowledge sharing, which PIONEER aims to support as part of the UroEvidenceHub initiative by the European Association of Urology.
Background: Novel technologies offer great possibilities for improving patient care, but their adoption varies across different European countries. To successfully integrate these advancements, it is crucial to prioritize patient interests and avoid getting side-tracked by issues that seek to preserve established positions or neglect collaboration. Next-generation sequencing and liquid biopsy in cancer patients hold substantial potential for early diagnosis and reducing suffering, but only if they are effectively implemented into routine health care.
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