Publications by authors named "D Holzapfel"
Article Synopsis
- Diagnosing Alzheimer's disease is tough for doctors, which can lead to delays in getting the right care for patients.
- Blood tests that check for signs of Alzheimer's could help doctors find the disease earlier and treat it better, but there are still some big challenges to overcome.
- A special group of leaders in Alzheimer's research is working on solutions, like creating better guidelines, training healthcare workers, and making sure patients understand their test results.
Article Synopsis
- Blood-based biomarkers (BBMs) are new tests that help doctors check for Alzheimer's disease in a simpler and cheaper way than older methods like brain scans or spinal fluid tests.! -
- A special group called the Global CEO Initiative on Alzheimer's Disease is suggesting two ways to use these BBMs: one for initial testing and another to confirm more serious cases.! -
- Using BBMs can make it easier for doctors to diagnose Alzheimer's, which means that patients can start getting needed treatments faster.!
Article Synopsis
- The study compares the oxidation resistance of HfB and HfAlB thin films at 700 °C over 8 hours, showing that HfAlB has significantly better performance with an oxide scale thickness only 14% of that of HfB after oxidation.
- The improved oxidation resistance of HfAlB is attributed to its dense, primarily amorphous oxide scale, which includes Hf, Al, and B, reducing oxidation kinetics due to passivation.
- HfAlB outperforms similar Ti-Al-based boride and nitride thin films, with reductions in oxide scale thickness of 21% compared to TiAlB and 47% compared to TiAlN, demonstrating effective oxidation resistance despite its
Anti-amyloid treatments for early symptomatic Alzheimer disease have recently become clinically available in some countries, which has greatly increased the need for biomarker confirmation of amyloid pathology. Blood biomarker (BBM) tests for amyloid pathology are more acceptable, accessible and scalable than amyloid PET or cerebrospinal fluid (CSF) tests, but have highly variable levels of performance. The Global CEO Initiative on Alzheimer's Disease convened a BBM Workgroup to consider the minimum acceptable performance of BBM tests for clinical use.
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