Publications by authors named "D Holtappels"

Bacterial black spot, caused by , is responsible for significant yield losses in lamb's lettuce () in many producing countries, especially Europe. Currently, no resistant varieties of are available that effectively control the disease under field conditions. Bacteriophage-based biocontrol has been suggested as a sustainable and natural alternative strategy to combat bacterial pathogens.

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The species complex is a heterogeneous group of plant pathogenic bacteria associated with a wide distribution of plant species. Advances in genomics are revealing the complex evolutionary history of this species complex and the wide array of genetic adaptations underpinning their diverse lifestyles. Here, we genomically characterize two isolates collected from diseased Callery pears () in Berkeley, California in 2019 and 2022.

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Bacteriophages are obligate parasites of bacteria characterized by the breadth of hosts that they can infect. This "host range" depends on the genotypes and morphologies of the phage and the bacterial host, but also on the environment in which they are interacting. Understanding phage host range is critical to predicting the impacts of these parasites in their natural host communities and their utility as therapeutic agents, but is also key to predicting how phages evolve and in doing so drive evolutionary change in their host populations, including through movement of genes among unrelated bacterial genomes.

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Article Synopsis
  • Biovar 1 is a soilborne pathogen that causes hairy root disease (HRD) in greenhouse plants, and current management strategies, like using hydrogen peroxide, face challenges due to resistant strains.
  • Six specific phages were isolated from biovar 1-infected greenhouses, which have a strict lytic lifestyle and remain stable in greenhouse conditions.
  • Testing on these phages revealed that while some effectively reduced bacterial concentrations without resistance, others led to phage resistance, indicating that these phages could potentially serve as an innovative solution for managing HRD.
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