Publications by authors named "D Hess"
Background: Older adults with cancer are at an increased risk of treatment related toxicities and early death. Routinely collected clinico-demographic characteristics inadequately explain this increased risk limiting accurate prognostication. Prior studies have suggested that altered body composition and frailty are independently associated with worse survival among older adults with cancer; however, their combined influence remains unclear.
View Article and Find Full Text PDFTraumatic brain injury (TBI) and stroke pose major health challenges, impacting millions of individuals globally. Once considered solely acute events, these neurological conditions are now recognized as enduring pathological processes with long-term consequences, including an increased susceptibility to neurodegeneration. However, effective strategies to counteract their devastating consequences are still lacking.
View Article and Find Full Text PDFCancer immunotherapies with antibodies blocking immune checkpoint molecules are clinically active across multiple cancer entities and have markedly improved cancer treatment. Yet, response rates are still limited, and tumour progression commonly occurs. Soluble and cell-bound factors in the tumour microenvironment negatively affect cancer immunity.
View Article and Find Full Text PDFArticle Synopsis
- Ischemic stroke can lead to severe disability and death, and researchers are investigating how the timing of a stroke impacts its severity, particularly focusing on the circadian clock protein Rev-Erbα.
- A study found that administering SR9009, a Rev-Erbα agonist, significantly reduced neuroinflammation and infarct size in mice when treated at specific times (ZT06 - during sleep) but not at other times (ZT18 - during wakefulness).
- The results suggest that SR9009 alters immune responses and may offer therapeutic benefits for stroke treatment, emphasizing the importance of timing in administering interventions.