Understanding sediment wash-off in road drainage systems under intense rainfall and high sediment masses: Insights from a large-scale modeling facility.

The main objective of this paper is to analyze, through a unique large-scale modeling facility, the RDS wash-off under various scenarios of intense rainfall and high RDS masses. A 1:1 scale physical modeling facility was used to allow precise measurement of the RDS wash-off phenomenon under two different rainfall intensities (30/50 mm/h) and three initial RDS masses (100/150/200 g/m). The accumulated and discharged masses of RDS in the different components of the modeling facility (roadway/RW, gully pot/GP and manhole/MH) were collected at the end of the wash-off simulations.

Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement.

COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 12 months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, has already infected over 160 million (>20% located in United States) and killed more than 3.3 million people around the world (>20% deaths in USA).

An open-source handheld extruder loaded with pore-forming bioink for wound dressing.

The increasing demand in rapid wound dressing and healing has promoted the development of intraoperative strategies, such as intraoperative bioprinting, which allows deposition of bioinks directly at the injury sites to conform to their specific shapes and structures. Although successes have been achieved to varying degrees, either the instrumentation remains complex and high-cost or the bioink is insufficient for desired cellular activities. Here, we report the development of a cost-effective, open-source handheld bioprinter featuring an ergonomic design, which was entirely portable powered by a battery pack.