Antifungal Peptides with Unexpected Structure from a Library of Synthetic Analogs of Host-Defense Peptide Rigin.

Rising antifungal resistance prompted the World Health Organization and the Food and Agriculture Organization to bring attention to the consequences of this threat to human, animal, and environmental health, and food security. In addition, there is an alarming cross-species pathogenicity. New antifungal agents are urgently needed, preferably with a low induction of antimicrobial resistance (AMR).

Natural history of patients with autosomal dominant pathogenic variants associated with sensorineural hearing loss and optic atrophy.

Objective: Autosomal dominant pathogenic variants in the WFS1 gene can cause a broad spectrum of WFS1-related disorders. These disorders present with a range of phenotypic manifestations, including isolated low-frequency sensorineural hearing loss, optic nerve atrophy accompanied by low- to mid-frequency sensorineural hearing loss, isolated diabetes mellitus, and early-onset cataracts. In general, WFS1-related disorders represent a milder spectrum of conditions linked to pathogenic WFS1 variants, except for Hattersley-Urano syndrome, which is characterized by early-onset diabetes mellitus, optic nerve atrophy, cataracts, hypotonia, intellectual disability, and developmental delay.

The role of autoantibodies in post-chikungunya viral arthritis disease severity.

Post-chikungunya viral arthritis may persist for months to years after infection and is characterized by relapsing and remitting symptoms. This study investigates the relationship between autoantibodies and chikungunya arthritis severity, providing insights into arthritis pathogenesis. We assessed arthritis measures in a cohort of serologically confirmed chikungunya cases from Colombia between 2019 and 2021 ( = 144).

Clinical Results of the ANAIS Study: Mechanical Thrombectomy Using the ANA Device in Combination with a Stent Retriever in Subjects with Acute Ischemic Stroke.

Background And Purpose: The ANA thrombectomy system is a funnel catheter comprising a self-expanding coated funnel that works in conjunction with a standard stent retriever and is designed to locally restrict flow and reduce clot fragmentation. The ANAIS Study to Confirm the Safety and Performance of the ANA 5F Advanced Neurovascular Access investigated the performance of the ANA funnel catheter in patients with stroke.

Materials And Methods: Mechanical thrombectomy using the ANA device in combination with a stent retriever in subjects with acute ischemic stroke.