Polymorphisms Influence the Expression of the Fas and FasL Genes in COVID-19.

The apoptotic molecule Fas and its ligand FasL are involved in the process of T-lymphocyte death, which may lead to lymphopenia, a characteristic of severe coronavirus disease 2019 (COVID-19). In this study, we investigated the influence of polymorphisms in the and genes, and gene expression, and plasma cytokine levels on COVID-19 severity and long COVID occurrence. A total of 116 individuals with severe COVID-19 and 254 with the non-severe form of the disease were evaluated.

An integrated multiphase dynamic genome-scale model explains batch fermentations led by species of the genus.

During batch fermentation, a variety of compounds are synthesized, as microorganisms undergo distinct growth phases: lag, exponential, growth-no-growth transition, stationary, and decay. A detailed understanding of the metabolic pathways involved in these phases is crucial for optimizing the production of target compounds. Dynamic flux balance analysis (dFBA) offers insight into the dynamics of metabolic pathways.

Co-Creation in the Development of Digital Therapeutics: A Narrative Review.

Digital therapeutics (DTx) are transforming healthcare delivery through personalised, evidence-based interventions that offer a cost-effective approach to health management. However, their widespread adoption faces significant barriers including privacy concerns, usability issues, and integration challenges within healthcare systems. This review assesses the current evidence on DTx, with a particular focus on the role of co-creation in enhancing design and usability.

Characterization of the complete mitogenome data of collared peccary, (Linnaeus, 1758) (Suina: Tayassuidae) from Ucayali, Peru.

The collared peccary ( Linnaeus, 1758) is a vital resource for the subsistence and economy of the Amazonian inhabitants. Despite its importance, there is a notable lack of genetic information on Peruvian collared peccary populations. This study presents the complete mitogenome of from Peru, obtained by Illumina sequencing.

The Impact of Cholecystectomy on the Metabolic Profile of Patients Previously Submitted to Bariatric Surgery.

Purpose: To evaluate the influence of late cholecystectomy following bariatric surgery on the postoperative evolution of weight loss and biochemical, metabolic, and micronutrient parameters.

Methods: A retrospective study that assessed 86 patients who underwent cholecystectomy after at least 18 months of bariatric surgery. The analyzed variables included demographic data, comorbidities, weight loss, and biochemical, metabolic, and micronutrient parameters.