Repetitive allogeneic intraarticular injections of synovial mesenchymal stem cells promote meniscus regeneration in a porcine massive meniscus defect model.

Objective: A new strategy is required in order to regenerate a meniscus for extensive defects. Synovial mesenchymal stem cells (MSCs) are an attractive cell source for meniscus regeneration due to their high proliferation and chondrogenic potential. We examined the effect of repetitive intraarticular injections of synovial MSCs on meniscus regeneration in a massive meniscal defect of pigs.

Intraarticular injection of synovial stem cells promotes meniscal regeneration in a rabbit massive meniscal defect model.

We investigated whether single intraarticular injection of synovial MSCs enhanced meniscal regeneration in a rabbit massive meniscal defect model. Synovium were harvested from the knee joint of rabbits, and the colony-forming cells were collected. Two weeks after the anterior half of the medial menisci were excised in both knees, 1 × 10(7) MSCs in 100 μl PBS were injected into the right knee.

Attachments of separate small bundles of human posterior cruciate ligament: an anatomic study.

Purpose: To date, there is no consensus on the detailed anatomy of the posterior cruciate ligament (PCL) and the most appropriate PCL reconstruction method. The purpose of this study is the detailed observation of separate small PCL bundles for better comprehension of detailed PCL anatomy to facilitate the design of anatomic PCL reconstruction.

Methods: Twelve cadaveric knees were used in this study.

Arthroscopic, histological and MRI analyses of cartilage repair after a minimally invasive method of transplantation of allogeneic synovial mesenchymal stromal cells into cartilage defects in pigs.

Background Aims: Transplantation of synovial mesenchymal stromal cells (MSCs) may induce repair of cartilage defects. We transplanted synovial MSCs into cartilage defects using a simple method and investigated its usefulness and repair process in a pig model.

Methods: The chondrogenic potential of the porcine MSCs was compared in vitro.