Publications by authors named "D Hartwig"

Combating multidrug-resistant is considered a priority by the World Health Organization. Virulence mechanisms, such as biofilm formation, multidrug resistance, and high adherence to both biotic and abiotic surfaces, underscore the urgency of exploring approaches to control this pathogen. The search for new antibiotic compounds and alternative strategies like immunotherapies and vaccination offers potential solutions to address this pressing health concern.

View Article and Find Full Text PDF

Background: Malignant hypercalcemia is usually caused by osteolytic processes of metastases, production of parathormone-related peptide, or secretion of 1,25-dihydroxyvitamin D. Ectopic PTH (parathyroid hormone) production by malignancy is very unusual.

Methods: Case report and review of the literature.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates antibiotic resistance and biofilm formation in Klebsiella pneumoniae strains from a university hospital in Pelotas, Brazil, highlighting the strains' persistence in hospital settings.
  • - Out of 28 K. pneumoniae isolates, a significant majority (96.42%) strongly formed biofilms, with 64.29% classified as multidrug-resistant (MDR), revealing a concerning level of antibiotic resistance.
  • - Genetic analysis showed 18 unique clones, indicating that the same strains circulated in different samples over two years, underscoring the need for improved control measures and disinfection protocols in hospital environments.
View Article and Find Full Text PDF

Introduction: The proportion of very elderly patients in the intensive care unit (ICU) is expected to rise. Furthermore, patients are likely more prone to suffer a cardiac arrest (CA) event within the ICU. The occurrence of intensive care unit cardiac arrest (ICU-CA) is associated with high mortality.

View Article and Find Full Text PDF

Acinetobacter baumannii is a bacteria associated with nosocomial infections and outbreaks, difficult to control due to its antibiotic resistance, ability to survive in adverse conditions, and biofilm formation adhering to biotic and abiotic surfaces. Therefore, this study aimed to evaluate the antibiofilm activity of biogenic silver nanoparticle (Bio-AgNP) and polymyxin B alone and combined in biofilms formed by isolates of carbapenem-resistant A. baumannii (CR-Ab).

View Article and Find Full Text PDF