Publications by authors named "D Hardy"
Unlabelled: The performance of the Liofilchem Compact Antimicrobial Susceptibility Panel (ComASP) Cefiderocol was evaluated in a multicenter study. Enterobacterales, , and clinical isolates and challenge isolates were tested by three and one sites, respectively. Minimum inhibitory concentration (MIC) testing was performed by the Clinical and Laboratory Standards Institute (CLSI) broth microdilution and ComASP, which included two reading endpoints (CLSI read; MIC is the first well in which reduction of growth is <1 mm or light haze/faint turbidity] and ComASP [ComASP read; MIC is the first well at which 100% inhibition of growth occurs]).
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- Researchers explored how combining DNA vaccination with a potent HBV neutralizing antibody might improve treatment for chronic HBV infections, which are hard to manage due to weak immune responses.
- In a study with mice, treatment with the antibody and a DNA vaccine led to the development of specific immune cells in the liver, enhancing immune recruitment but also indicating T cells became dysfunctional over time.
- While this combination therapy did not fully cure the infection, it showed promise by improving the immune response and providing insights into how the liver tolerates HBV.
Hypothesis: Supra-particle formation by evaporation of an aqueous aerosol droplet containing nano-colloidal particles is challenging to investigate but has significant applications. We hypothesise that the Peclet number, Pe, which compares the effectiveness of evaporation-induced advection to that of colloidal diffusion, is critical in determining supra-particle morphology and can be used to predict the dried morphology for droplet containing polydisperse nanoparticles.
Experiments: Sterically-stabilized diblock copolymer nanoparticles were prepared via polymerization-induced self-assembly (PISA).
Article Synopsis
- A novel human circovirus, named HCirV-1, was discovered in a 66-year-old immunocompromised woman suffering from sudden hepatitis.
- Researchers found HCirV-1 genetic material in the patient's liver cells and also in her blood, stool, and urine over an extended period.
- HCirV-1 is recognized as an emerging human pathogen that can persist in individuals with weakened immune systems.