Publications by authors named "D Haouzi"

Article Synopsis
  • Endocrine-disrupting chemicals, like TCDD, may play a role in increasing female-specific cancers in Western countries, particularly affecting reproductive health.
  • The study focused on how TCDD exposure alters the expression of small noncoding RNAs (sncRNAs) in KGN cells, examining both acute (3 hours) and chronic (72 hours) effects, and their implications for subsequent cell generations.
  • Results showed that TCDD exposure led to a significant alteration in sncRNA expression, with a downregulation of sncRNAs associated with cell growth and proliferation, and an upregulation of those linked to cancer, suggesting the potential for TCDD to cause long-term cancer-promoting effects across generations.
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Understanding whether SARS-CoV-2 could infect cells and tissues handled during ART is crucial for risk mitigation, especially during the implantation window when either endometrial biopsies are often practiced for endometrial receptivity assessment or embryo transfer is performed. To address this question, this review analyzed current knowledge of the field and retrospectively examined the gene expression profiles of SARS-CoV-2-associated receptors and proteases in a cohort of ART candidates using our previous Affymetrix microarray data. Human endometrial tissue under natural and controlled ovarian stimulation cycles and preimplantation embryos were analyzed.

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Article Synopsis
  • * The results showed that the biphasic strategy led to significantly higher rates of total and usable blastocysts and an increased live birth rate.
  • * Additionally, gene analysis indicated that the oxygen concentration influenced the expression of genes related to embryo development and implantation, suggesting a biological basis for the improved outcomes with the biphasic method.
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Article Synopsis
  • - The study analyzes the miRNome (microRNA profile) of endometrial samples during the implantation window to see if it can predict outcomes in Assisted Reproduction Technology (ART) for patients with repeated implantation failures (RIF).
  • - It involves a discovery cohort of 20 patients to identify various miRNAs associated with receptivity and outcomes like early miscarriage or live birth, followed by a validation cohort of 103 RIF patients to confirm findings with RT-qPCR.
  • - Ultimately, four specific miRNAs are significantly linked to endometrial receptivity and implantation failure, suggesting that analyzing these profiles could help predict pregnancy success and enhance ART effectiveness.
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