Publications by authors named "D Hanley"
Introduction: In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, to support transfusion for two outpatient randomized controlled trials. The center design was based on an investigational drug services model and a Food and Drug Administration-compliant database to manage blood product inventory and trial safety.
Methods: A core investigational team adapted a cloud-based platform to randomize patient assignments and track inventory distribution of control plasma and high-titer COVID-19 convalescent plasma of different blood groups from 29 donor collection centers directly to blood banks serving 26 transfusion sites.
Code ICH: reorganising stroke care for intracerebral haemorrhage.
J Neurol Neurosurg Psychiatry
November 2024
Article Synopsis
- The study investigates how the number of mechanical thrombectomy (MT) procedures performed annually at hospitals affects patient outcomes for acute ischemic stroke in the U.S. from 2016 to 2020.
- It found that as MT procedural volume increases, patients had lower rates of being discharged home/self-cared and higher odds of in-hospital mortality and post-treatment intracranial hemorrhage (ICH).
- The results suggest a paradox where higher procedural volume at hospitals correlates with worse outcomes, likely due to treating more severe cases at these high-volume centers.
Article Synopsis
- - The study analyzed individual patient data from multiple trials to assess sex-specific differences in clinical characteristics and outcomes of patients with spontaneous intracerebral hemorrhage (ICH).
- - Results showed that while males were younger and had larger brain bleeds and a higher risk of bleed expansion compared to females, they also had a lower risk of poor functional outcomes.
- - The findings indicate distinct biological and clinical pathways in males and females with ICH, emphasizing the need for targeted research based on sex differences in this condition.
The quotation, attributed to Confucius many centuries ago, in our opinion, applies to the evolving story of defining a primary surgical treatment for spontaneous intracerebral hemorrhage. The precise quote is: "Keep it simple and focus on what matters. Don't let yourself be overwhelmed.
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