Mitochondria-targeted oligomeric α-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson's disease and parkinsonism-dementia of Guam.

Mitochondrial dysfunction is a central aspect of Parkinson's disease (PD) pathology, yet the underlying mechanisms are not fully understood. This study investigates the link between α-Synuclein (α-Syn) pathology and the loss of translocase of the outer mitochondrial membrane 40 (TOM40), unraveling its implications for mitochondrial dysfunctions in neurons. We discovered that TOM40 protein depletion occurs in the brains of patients with Guam Parkinsonism-Dementia (Guam PD) and cultured neurons expressing α-Syn proteinopathy, notably, without corresponding changes in TOM40 mRNA levels.

Evidence-Based Design and Liability Risks for Health Care Organizations.

Since the 1980s, science about how built environments influence human health has been used by architects, engineers, and designers to inform decisions about health care organizations' structures and spaces. Because design influences health outcomes, ignoring evidence-based design can be a source of clinical, ethical, legal, and organizational liability. This article introduces concepts related to designs' influence on patient and community health outcomes and suggests strategies for health-legal partnering to promote rigor in health care organizational design practices that promote quality and equity in health service delivery.

'How Long Do I Have?' - Examining survival outcomes in laryngeal cancer patients managed with non-curative intent in Northern UK: Insights from the Northern Head & Neck Cancer Alliance Retrospective Study.

Introduction: Historically, 15% of laryngeal cancer patients undergo non-curative management, but pragmatic data on this group are limited. This information is crucial to help patients make informed decisions about their care. Supported by the Northern Head & Neck Alliance, this retrospective study is the first to present survival outcomes for non-curative laryngeal cancer patients in Northern UK.

Establishing Indicative Neurofilament Gradients based on Severity of Spinal Cord Injury.

Introduction: Acute traumatic spinal cord injury (SCI) results in a lifelong condition without any standardized biomarker or corresponding interventions. The objective of this study was to correlate changes in fluid biomarkers with the severity of SCI.

Methods: The test model used forces of 100 and 200 kdyn.