Impact of minimal invasive extracorporeal circulation on systemic inflammatory response - a randomized trial.

Background: Extracorporeal circulation causes a systemic inflammatory response, that may cause postoperative haemodynamic instability and end-organ dysfunction. This study aimed to investigate the impact of minimal invasive extracorporeal circulation (MiECC) on the systemic inflammatory response compared with conventional extracorporeal circulation (CECC).

Methods: Patients undergoing coronary artery bypass grafting were randomized to MiECC (n = 30) and CECC (n = 30).

CCAT1 lncRNA is chromatin-retained and post-transcriptionally spliced.

Super-enhancers are unique gene expression regulators widely involved in cancer development. Spread over large DNA segments, they tend to be found next to oncogenes. The super-enhancer c-MYC locus forms long-range chromatin looping with nearby genes, which brings the enhancer and the genes into proximity, to promote gene activation.

A conventional-to-spectral CT image translation augmentation workflow for robust contrast injection-independent organ segmentation.

Purpose: In computed tomography (CT) cardiovascular imaging, the numerous contrast injection protocols used to enhance structures make it difficult to gather training datasets for deep learning applications supporting diverse protocols. Moreover, creating annotations on noncontrast scans is extremely tedious. Recently, spectral CT's virtual-noncontrast images (VNC) have been used as data augmentation to train segmentation networks performing on enhanced and true-noncontrast (TNC) scans alike, while improving results on protocols absent of their training dataset.

Spectral augmentation for heart chambers segmentation on conventional contrasted and unenhanced CT scans: an in-depth study.

Purpose: Recently, machine learning has outperformed established tools for automated segmentation in medical imaging. However, segmentation of cardiac chambers still proves challenging due to the variety of contrast agent injection protocols used in clinical practice, inducing disparities of contrast between cavities. Hence, training a generalist network requires large training datasets representative of these protocols.

Impact of minimally invasive extracorporeal circulation on coagulation-a randomized trial.

Objectives: Minimally invasive extracorporeal circulation (MiECC) is suggested to have favourable impact on blood loss compared to conventional extracorporeal circulation. We aimed to compare the impact of both systems on coagulation.

Methods: Randomized trial comparing endogenous thrombin-generating potential early after elective coronary surgery employing either MiECC group (n = 30) or conventional extracorporeal circulation group (n = 30).