Publications by authors named "D Haldane"
Article Synopsis
- The study focused on invasive group A Streptococcus trends in Canada by analyzing emm1 isolates from 2018 to 2023.
- There was a notable rise in hypervirulent M1 lineage isolates, increasing from 22.1% to 60.2% during this period.
- Genomic analysis revealed clusters linked to specific locations and times, as well as genes tied to the acquisition of virulent bacteriophages.
Article Synopsis
- Invasive pneumococcal disease (IPD) has been monitored in Canada since 2000, highlighting shifts in serotype distribution due to conjugate vaccines, with a report summarizing data from 2021 and 2022 on demographics, serotypes, and antimicrobial resistance.
- The National Microbiology Laboratory collaborated with public health labs across Canada, reporting nearly 2,000 isolates in 2021 and nearly 3,800 in 2022, using various methods for serotype determination and susceptibility testing.
- While IPD cases decreased to 5.62 per 100,000 population in 2021, 2022 saw a rise back to pre-pandemic levels, with notable increases in certain serotypes
Background: Invasive group A streptococcal (iGAS, ) disease has been a nationally notifiable disease in Canada since 2000. This report summarizes the demographics, types, and antimicrobial resistance of iGAS isolates collected in Canada in 2021 and 2022.
Methods: The Public Health Agency of Canada's National Microbiology Laboratory collaborates with provincial and territorial public health laboratories to conduct national surveillance of invasive .
Article Synopsis
- Gonorrhea is a major public health issue in Canada, being the second most common bacterial STI, and the Gonococcal Antimicrobial Surveillance Programme has been tracking its antimicrobial resistance since 1985.
- In 2021, Canada saw a 9.9% increase in gonococcal cultures submitted, revealing growing resistance to cefixime and identifying one ceftriaxone-resistant isolate, despite no significant changes in ceftriaxone resistance overall.
- The monitoring highlights a significant public health threat due to rising antimicrobial resistance, underscoring the necessity for ongoing surveillance to inform effective treatment options.*
Article Synopsis
- This study aims to analyze the genetic backgrounds and resistance traits of common pneumococcal serotypes in Canada over the past five years, focusing on their behavior after the introduction of the PCV13 vaccine.
- Researchers sequenced the genomes of a sample from the ten most prevalent serotypes and used this data to identify important characteristics, including virulence and antimicrobial resistance (AMR) genes.
- The results revealed significant changes in the prevalence of certain serotypes, with some increasing in numbers and one, 19A, decreasing, highlighting the need for ongoing surveillance to track new bacterial lineages and AMR development in Canada.