Role of patient preferences in clinical practice guidelines: a multiple methods study using guidelines from oncology as a case.

Objective: Many treatment decisions are preference-sensitive and call for shared decision-making, notably when benefits are limited or uncertain, and harms impact quality of life. We explored if clinical practice guidelines (CPGs) acknowledge preference-sensitive decisions in how they motivate and phrase their recommendations.

Design: We performed a qualitative analysis of the content of CPGs and verified the results in semistructured interviews with CPG panel members.

Long-term efficacy and tolerability of rizatriptan wafers in migraine.

Context: Rizatriptan is a selective 5-HT1B/1D receptor agonist for the acute treatment of migraine. It is available in a unique wafer formulation that dissolves rapidly in the mouth and can be taken without liquids, thereby offering patients a very convenient way to take treatment.

Objective: To investigate the long-term efficacy of rizatriptan 10-mg and 5-mg wafers in migraineurs.