Publications by authors named "D Haigh"
Article Synopsis
- - Tularemia, caused by the bacterium Francisella tularensis, is typically absent in the UK.
- - A case of tularemia was diagnosed in a UK patient in July 2023, who hadn't traveled in the six weeks leading up to their symptoms.
- - A multiagency investigation was launched to explore how the patient might have contracted the disease.
Article Synopsis
- * A biopsy confirmed the presence of tuberculosis, prompting a treatment plan involving a combination of antibiotics over several months.
- * The case highlights the need for awareness of tuberculosis in joint issues and the advantages of using advanced diagnostic techniques like whole genome sequencing for quicker treatment to reduce complications.
Objectives: A novel 'subscription-type' funding model was launched in England in July 2022 for ceftazidime/avibactam and cefiderocol. We explored the views of infection consultants on important aspects of the delinked antimicrobial funding model.
Methods: An online survey was sent to all infection consultants in NHS acute hospitals in England.
Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types, including prostate cancer (PCa). Both KDM1A and KDM5B interact with AR and promote androgen regulated gene expression.
View Article and Find Full Text PDFN-methyladenosine (mA) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the mA modification. These proteins, and the mA modification, are involved in the regulation of gene expression, RNA stability, splicing and translation. Given its role in these crucial processes, mA has been implicated in many diseases, including in cancer development and progression.
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