Genetic determination of chromosomal radiosensitivities in G0- and G2-phase human lymphocytes.

Background And Purpose: The radiosensitivity of human lymphocytes measured using a G0- or G2-assay has been linked with an individual's risk of developing normal tissue complications following radiotherapy. This study was performed to increase basic knowledge of the genetics of the human radiation response, and chromosomal aberration induction in particular.

Materials And Methods: The study was carried out with blood samples taken from 15 monozygotic twin pairs.