RPS23RG1 inhibits SORT1-mediated lysosomal degradation of MDGA2 to protect against autism.

Mutations in the synaptic protein MAM domain containing glycosylphosphatidylinositol anchor 2 (MDGA2) have been associated with autism spectrum disorder (ASD). Therefore, elucidating the regulatory mechanisms of MDGA2 can help develop effective treatments for ASD. Liquid chromatography-tandem mass spectrometry was carried out to identify proteins interacting with the extracellular domain of RPS23RG1 and with MDGA2, followed by co-immunoprecipitation assays to confirm protein-protein interactions.

Composite barrier membrane for bone regeneration: advancing biomaterial strategies in defect repair.

Bone defects represent a significant challenge in clinical practice, driving the need for innovative solutions that effectively support bone regeneration. Barrier membranes, due to playing a critical role in creating an environment conducive to bone regeneration by preventing the infiltration of non-osteogenic tissues, are widely applied to bone repair. However, inadequate spatial stability and osteogenesis-promoting ability often limit current barrier membranes.

Ultraviolet-Shielded Transparent Wood with Improved Interface for Insulating Windows.

Recently, transparent wood (TW) has been considered for many energy-efficient building products, such as windows and decorations. However, the existing TW still faces issues with size and thickness, as well as problems with functional fillers affecting the optical and mechanical properties of TW, which limits its wide application in the window products. In this study, a wood composite material (WCM) with good optical, mechanical, and thermal insulation and UV-shielding properties was prepared by using delignified wood (DW), methyl methacrylate (MMA), and 4-vinylphenylboric acid (VPBA).

Will the increase of medical equipment affect medical expenditure? Empirical evidence from a quasi-experiment in China.

Background: Many studies have shown that using new technologies and medical equipment contributes to increasing health expenditure. Relatively less empirical studies have measured the impact of medical equipment on rising medical costs in China. Against this backdrop, we aim to examine whether the large-scale medical equipment deployment explains the increase in health expenditure.