Identification of a key peptide cyclase for novel cyclic peptide discovery in Pseudostellaria heterophylla.

Orbitides, also known as Caryophyllaceae-type cyclic peptides, from Traditional Chinese Medicine plant Pseudostellaria heterophylla (Mil.) Pax have great potential for improving memory and treating diabetes. Orbitides are ribosomally encoded and post-translationally modified peptides, but this key biosynthesis enzyme is still unknown in P.

Selective C(sp)-P Cross-Coupling of Alkenylsulfonium Salts with P(O)H Compounds: Divergent Synthesis of Alkenylphosphorus Compounds.

Herein, we report a both regioselective and stereoselective method for the formation of C(sp)-P bonds using alkenylsulfonium salts and >P(O)-H compounds. By employing a palladium catalyst or KCO, a variety of ()-alkenylphosphorus compounds and terminal alkenylphosphorus compounds were successfully synthesized with high selectivity. Notably, trisubstituted ()-alkenylphosphorus compounds were synthesized for the first time under metal-free conditions.

Rapeseed and Palm Oils Can Improve the Growth, Muscle Texture, Fatty Acids and Volatiles of Marine Teleost Golden Pompano Fed Low Fish Oil Diets.

This study evaluated the effects of different lipid sources-fish oil (FO), soybean oil, rapeseed oil, and palm oil-on the growth and muscle quality of golden pompano () cultured in offshore cages for 10 weeks. Three diets (D1-D3) were formulated: D1 used only fish oil, D2 blended fish, rapeseed oil, and palm oil, and D3 combined fish and soybean oils. Fish in the D1 group showed the highest weight gain, specific growth rate, and muscle protein content, significantly outperforming D3.

The clinical characteristics of 10 cases and adult height of six cases of rare familial male-limited precocious puberty.

Objectives: Familial Male-Limited Precocious Puberty (FMPP) is a rare autosomal-dominant genetic condition with sexual dimorphism. We aim to summarize the clinical characteristics of FMPP patients and emphasize the use of a therapeutic regimen involving letrozole, spironolactone, and GnRHa, to augment clinician's understanding of the disease, thus enhancing patient care.

Methods: We retrospectively analyzed the clinical data of 10 FMPP patients and conducted follow-up assessments of adult height in six patients.