Publications by authors named "D H Weintraub"
Asynchronous bilateral hematomas are exceedingly rare and pose increased risk and challenge during surgical treatment. In this case report, a 31-year-old male patient was initially found to have only a large left-sided epidural hematoma which was subsequently evacuated. An immediate postoperative CT scan demonstrated a new right-sided epidural hematoma.
View Article and Find Full Text PDFPurpose: Anticholinergic medication use measured via the Anticholinergic Cognitive Burden (ACB) scale has been associated with an increased dementia incidence in older adults but has not been explored specifically for Parkinson disease dementia (PDD). We used adjusted Cox models to estimate the risk of incident PDD associated with demographic factors, clinical characteristics, and time-varying total ACB in a longitudinal, deeply-phenotyped prospective PD cohort.
Major Findings: 56.
Article Synopsis
- Fall risk and cognitive impairment are common issues in Parkinson's disease, necessitating effective treatments.
- The study evaluated the safety and efficacy of TAK-071, a targeted medication, in individuals with Parkinson's who also experience these challenges.
- Despite not showing significant improvement in gait variability, TAK-071 was found to enhance cognitive function, marking a potential positive outcome for patients.
Article Synopsis
- Cognitive impairment is prevalent in Parkinson's disease (PD), but there's no agreement on the best neuropsychological tests to assess it; a Cognitive Summary Score (CSS) combines various tests into a single score for easier interpretation.
- This study aimed to see if a CSS, developed using strong norming methods, could identify early cognitive issues in untreated PD patients.
- Results show that PD patients performed worse than healthy controls across cognitive tests, especially in processing speed and verbal memory, and the CSS provided a more sensitive measure of cognitive decline than individual tests.
Objectives: To determine the impact of dopamine deficiency and isolated REM sleep behavior disorder (iRBD) on cognitive performance in early neuronal alpha-synuclein disease (NSD) with hyposmia.
Methods: Using Parkinson's Progression Markers Initiative baseline data, cognitive performance was assessed with a cognitive summary score (CSS) developed by applying regression-based internal norms derived from a robust healthy control (HC) group. Performance was examined for participants with hyposmia classified as NSD-Integrated Staging System (NSD-ISS) Stage 2, either Stage 2A (CSF alpha-synuclein seed amplification assay [SAA]+, SPECT dopamine transporter scan [DaTscan]-) or 2B (SAA+, DaTscan+).