Publications by authors named "D H Souza"
Mitochondrial oxidative phosphorylation (OXPHOS) is a therapeutic vulnerability in glycolysis-deficient cancers. Here we show that inhibiting OXPHOS similarly suppresses the proliferation and tumorigenicity of glycolytically competent colorectal cancer (CRC) cells in vitro and in patient-derived CRC xenografts. While the increased glycolytic activity rapidly replenished the ATP pool, it did not restore the reduced production of aspartate upon OXPHOS inhibition.
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- The Psychiatry Information Card (PIC) is a structured resource designed to boost medical students' confidence and knowledge during their psychiatry rotations, aiding their transition from classroom to clinical practice.
- The PIC improves pre- and post-rotation knowledge and learning experiences, with a high recommendation rate (90%) indicating strong student support for its use in rotations.
- Due to its low cost and easy distribution, the PIC is seen as a viable resource for broader integration into medical education curricula.
This paper develops the methodological concept of river co-learning arenas (RCAs) and explores their potential to strengthen innovative grassroots river initiatives, enliven river commons, regenerate river ecologies, and foster greater socio-ecological justice. The integrity of river systems has been threatened in profound ways over the last century. Pollution, damming, canalisation, and water grabbing are some examples of pressures threatening the entwined lifeworlds of human and non-human communities that depend on riverine systems.
View Article and Find Full Text PDFStoma reversal surgery is known for relatively high complication rates. While Enhanced Recovery After Surgery (ERAS) protocols are extensively validated for colorectal surgery, their use in stoma reversal remains underexplored. This systematic review and meta-analysis evaluates clinical outcomes of stoma reversal surgery under ERAS protocols compared to standard care (SC) practices.
View Article and Find Full Text PDFThe aim of this study was to evaluate the proteolytic profile of the cell-free crude extract (CFCE) of Pleurotus djamor and its nematicidal action on Haemonchus spp. and Trichostrongylus spp. larvae in coprocultures.
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