Publications by authors named "D H Small"
Acute myeloid leukemia (AML) patients with the FMS-related receptor tyrosine kinase 3 internal tandem duplication (FLT3/ITD) mutation have a poorer prognosis, and treatment with FLT3 tyrosine kinase inhibitors (TKIs) has been hindered by resistance mechanisms. One such mechanism is known as adaptive resistance, in which downstream signaling pathways are reactivated after initial inhibition. Past work has shown that FLT3/ITD cells undergo adaptive resistance through the reactivation of extracellular signal-regulated kinase (ERK) signaling within 24 h of sustained FLT3 inhibition.
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- Point-of-care testing (PoCT) is evaluated as a beneficial alternative for diagnosing and treating critically ill children with cerebral malaria in Malawi.
- In a study of 193 children, over half (52.1%) had abnormal PoCT results, impacting clinical interventions in only 16.9% of cases.
- Higher mortality risks were observed in patients with specific conditions like hypoglycemia and hyperlactatemia, highlighting the need for further research on PoCT's effectiveness in improving patient outcomes.
Article Synopsis
- - SLPI is a key protein that plays a role in airway immunity by inhibiting harmful enzymatic activity, and it also has anti-inflammatory effects by regulating immune responses through NF-κB inhibition.
- - In lung diseases like COPD and Cystic Fibrosis, SLPI levels can be elevated due to inflammation, but some studies show that COPD patients may have lower SLPI levels, which could weaken airway immunity.
- - Researchers are using a mouse model that mimics features of COPD and CF to study the effects of SLPI by creating a genetically modified mouse (ENaC-Tg/SLPI) to understand how the absence of SLPI influences the progression of these chronic lung diseases.
Article Synopsis
- - The text highlights the importance of secure firearm storage in preventing youth firearm injuries and deaths in the U.S., with pediatric clinicians not consistently utilizing available programs despite recommendations from the American Academy of Pediatrics.
- - The study aimed to evaluate the effectiveness of two different support methods—an electronic health record template (nudge) and an enhanced version with additional clinic support (nudge+)—in promoting a secure firearm storage program during pediatric visits.
- - Conducted across 30 pediatric clinics in Michigan and Colorado, the trial sought to determine if the nudge+ approach would increase the delivery of the firearm storage program to at least 10% more eligible families compared to the nudge alone.
Randomized clinical trials (RCTs) often suffer from a lack of representation from historically marginalized populations, and it is uncertain whether virtual RCTs (vRCTs) enhance representativeness or if elements of their consent and enrollment processes may instead contribute to underrepresentation of these groups. In this study, we aimed to identify disparities in enrollment demographics in a vRCT, the BE ACTIVE study, which recruited patients within a single health system. We discovered that the proportions of eligible patients who were randomized differed significantly by gender and race/ethnicity (men 1.
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