Correction: Redox correlation in muscle lengthening and immune response in eccentric exercise.

[This corrects the article DOI: 10.1371/journal.pone.

Redox correlation in muscle lengthening and immune response in eccentric exercise.

This study was designed to examine the potential involvement of reactive oxygen species in skeletal muscle dysfunction linked with stretching in a mouse model and to explore the effects of combined antioxidant intake on peripheral leukocyte apoptosis following eccentrically-biased downhill runs in human subjects. In the mouse model, diaphragmatic muscle was stretched by 30% of its optimal length, followed by 5-min contraction. Muscle function and extracellular reactive oxygen species release was measured ex vivo.

Does combined antioxidant vitamin supplementation blunt repeated bout effect?

We investigated the effect of antioxidant supplementation on markers of muscle damage, antioxidant status, and delayed onset of muscle soreness (DOMS) after repeated downhill runs. Moderately-trained males (n=22) were randomly assigned to a supplement (S) or placebo (P) group. Capsules (vitamin C:1 000 mg/d; vitamin E: 400 IU/d) were ingested daily for 2 weeks.

Resistance exercise training-induced decrease in circulating inflammatory CD14+CD16+ monocyte percentage without weight loss in older adults.

Purpose: Exercise training reduces systemic inflammation in weight-stable people, but concurrent diet-induced body weight loss is not well studied. We hypothesized that resistance training would decrease inflammatory monocyte percentage and improve biomarkers associated with disease risk, independent of weight loss.

Methods: Forty physically inactive (PI) subjects (58.

Leukocyte apoptosis and pro-/anti-apoptotic proteins following downhill running.

The purposes of this study were to determine the effect of eccentric exercise-induced muscle damage on the induction of apoptosis in peripheral blood leukocytes and to investigate if the elevation in apoptotic leukocytes was mediated by changes in the concentration of anti-/pro-apoptotic proteins in circulation. Twelve moderately trained subjects performed three 40 min treadmill runs at ~70% VO(2max): a level run (L) followed by two downhill runs (DH1 and DH2). Blood samples were taken at rest (PRE) and immediately (POST), 2, 24, and 48 h after each run.