Publications by authors named "D H Schweitzer"
Sirtuins (SIRTs), nicotine adenine dinucleotide (+)-dependent histone deacetylases, have emerged as critical regulators in many signalling pathways involved in a wide range of biological processes. Currently, seven mammalian SIRTs have been characterized and are found across a number of cellular compartments. There has been considerable interest in the role of SIRTs in the brain due to their role in a plethora of metabolic- and age-related diseases, including their involvement in learning and memory function in physiological and pathophysiological conditions.
View Article and Find Full Text PDFPowassan virus (POWV) is a pathogenic tick-borne flavivirus that causes fatal neuroinvasive disease in humans. There are currently no approved therapies or vaccines for POWV infection. Here, we develop a POW virus-like-particle (POW-VLP) based vaccine adjuvanted with the novel synthetic Toll-like receptor 7/8 agonist INI-4001.
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- Fragility pelvic fractures are becoming more common due to increased life expectancy, often requiring surgery with ilio-sacral screws for stabilization.* -
- This review discusses a novel, low-cost cement augmentation technique for ilio-sacral screws, designed for patients with poor bone quality and includes case examples from five patients treated between 2017 and 2024.* -
- The new surgical method is straightforward and uses readily available instruments, but further research is needed to prove its efficacy compared to traditional techniques without cement augmentation.*
Background: People living with Parkinson's disease (PD) commonly experience heat sensitivity-worsening symptoms and restricted daily activities in heat.
Objective: This study aimed to develop a scale of heat sensitivity for people with PD.
Methods: Through a search of the scientific literature and online forums, we developed 41 items relating to experiences of heat for people with PD to assess heat sensitivity.
Background: In 2021, an estimated 43% of the world's population had been diagnosed with a neurological disorder. Early life stress (ELS) is now a well-established risk factor for later-life neurological disorders. However, translation to clinical practice is hindered by oversimplification, lack of standardisation and limited knowledge of the patterns and mechanisms of disease pathogenesis.
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