Publications by authors named "D H Sakai"

Intervertebral disc degeneration is a leading cause of chronic low back pain, affecting millions globally. Regenerative medicine, particularly cell-based therapies, presents a promising therapeutic strategy. This study evaluates the comparative efficacy of two biomaterials-hyaluronic acid (HA) and alginate-as carriers for nucleus pulposus (NP) cell transplantation in a beagle model of induced disc degeneration.

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Article Synopsis
  • * Out of 451 patients over 65 years with cervical fractures, 69% had mid-cervical injuries while 31% had lower-cervical injuries, with lower-cervical injuries being linked to more high-energy trauma cases.
  • * Although lower-cervical injuries resulted in fewer muscle weaknesses compared to mid-cervical injuries, many patients still experienced neurological deficits and similar overall complication rates after treatment, such as respiratory issues but no significant differences in mortality or mobility outcomes.
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Introduction: Preoperative estimations of blood loss are important when planning surgery for cervical spine injuries in older adults. The association between ankylosis and blood loss in perioperative management is of particular interest. This multicenter database review aimed to evaluate the impact of ankylosis on surgical blood loss volume in elderly patients with cervical spine injury.

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Planktonic larvae of sessile metazoans select substrates for settlement based on various factors. larvae (Ascidiacea: Phlebobranchia: Ascidiidae) showed a negative preference for nano-scale nipple arrays (dense arrays of papillae-like nanostructures approximately 100 nm in height). To clarify whether ascidian larvae discriminate between nano-structure sizes for substrate selection, three different sizes of periodic nano-folds were fabricated using two-beam interference exposure, and substrate selection assays were performed on the three types of nano-folds and flat surfaces made of the same material.

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