Publications by authors named "D H SANDBERG"
Mental Health Issues Associated With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
J Clin Endocrinol Metab
January 2025
Context: The goal of this review is to move beyond summarizing what is known about psychosexual development in females with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency-commonly studied as a natural experiment to understand prenatal androgen effects in 46,XX individuals. Instead, it will explore the various aspects of the condition that significantly impact the daily lives of both male and female patients and their families, with a particular focus on the implications for psychosocial, educational, and vocational adaptation.
Evidence Acquisition: This work represents a selective, yet balanced review of papers highlighting potential threats to positive psychological adaptation in both male and female individuals with CAH.
Article Synopsis
- The study examines the mental health challenges faced by patients with classic congenital adrenal hyperplasia (CAH) compared to matched groups from the general population and women with type-1 diabetes mellitus (T1DM).
- Researchers found that CAH patients showed higher rates of psychiatric issues, like depression and anxiety, than those in the general population, but similar rates to those with T1DM.
- The findings suggest that while living with CAH contributes to mental health problems, it may intersect with issues faced by individuals managing any chronic medical condition, highlighting the need for further research on their long-term mental health outcomes.
Tannins are critical plant defense metabolites, enriched in bark and leaves, that protect against microorganisms and insects by binding to and precipitating proteins. Hydrolyzable tannins contain ester bonds which can be cleaved by tannases-serine hydrolases containing so-called "cap" domains covering their active sites. However, comprehensive insights into the biochemical properties and structural diversity of tannases are limited, especially regarding their cap domains.
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- - The study explored the use of acellular dermal regeneration templates (ADRT) to heal myelomeningoceles in newborns, a condition that poses risks due to central nervous system infections and challenges in surgical repair.
- - A review of seven cases revealed that many patients experienced complications from previous repair attempts, leading to the need for ADRT to enhance the healing process and protect vital structures.
- - Results showed that after ADRT placement, four patients developed healthy granulation tissue within three weeks, and all wounds healed without infections, suggesting ADRT is a promising option for difficult myelomeningocele repairs.
The reaction of wood with maleic anhydride (MA) and sodium hypophosphite (SHP) has been identified as a viable modification method, with macroscopical properties indicating formation of cross-linking to explain the results. However, the chemical reaction between wood and the modification reagents has not been studied yet. To resolve this, the reaction was studied with solid-state C cross-polarization magic-angle-spinning (CP-MAS) and P MAS nuclear magnetic resonance (NMR) and X-ray photoelectron spectroscopy (XPS) to reveal the formation of bonds between wood components, MA and SHP during the treatments to explain the formation of cross-linking and the possible fixation of phosphorus in wood.
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