Publications by authors named "D H Krueger"
Objective: Tuberous sclerosis complex (TSC) results from overactivity of the mechanistic target of rapamycin (mTOR). Sirolimus and everolimus are mTOR inhibitors that treat most facets of TSC but are understudied in infants. We sought to understand the safety and potential efficacy of preventative sirolimus in infants with TSC.
View Article and Find Full Text PDFObjective: Peer recovery support specialists (PRSS) are essential members of the behavioral health workforce. While factors contributing to PRSS job satisfaction and burnout have been examined, less is understood about why PRSS consider leaving or remaining in their roles. This study sought to identify personal, professional, and organizational factors related to PRSS' intentions to leave their current position.
View Article and Find Full Text PDFArticle Synopsis
- The mammalian pancreas has three key parts: exocrine acini and ducts, along with endocrine islets, all originating from a common progenitor during development.
- Researchers created 18 human fetal pancreas organoid lines from samples between 8-17 weeks of gestation, with four lines showing the ability to produce all three cell types while thriving in culture for over two years.
- Single-cell RNA sequencing revealed LGR5 cells as crucial developmental stem cells, indicating that these organoids are capable of long-term growth and can differentiate into acinar, ductal, and endocrine cells.
Article Synopsis
- A rare, gram-negative, non-fermenting bacterium was identified as a potential pathogen linked to musculoskeletal infections, with a documented case found in an 80-year-old female after hip fracture surgery.
- The patient suffered from tenderness and swelling at the surgical site six months post-operation, leading to the diagnosis of an osteosynthesis-associated infection (OAI) confirmed by microbiological tests.
- Treatment involved a two-stage surgical revision and a two-month antibiotic regimen, resulting in the patient being infection-free and satisfied two years after the surgery.
Article Synopsis
- The study investigates the relationship between early seizures and intellectual disability in children with tuberous sclerosis complex (TSC), focusing on how timing and frequency of seizures affect development.
- Researchers analyzed data from 129 TSC patients over 36 months, using machine learning to identify neurodevelopmental subgroups and effective biomarkers for predicting outcomes.
- Findings indicate that the total number of seizures (accumulated seizure burden) is a stronger predictor of cognitive development at 36 months than the age at which seizures begin, highlighting the importance of seizure management for better developmental outcomes.