Exploring the Anti-Osteoporotic Effects of -Hexane Fraction from Nakai: Activation of Runx2 and Osteoblast Differentiation In Vivo.

Background: Osteoporosis is characterized by the microstructural depletion of bone tissue and decreased bone density, leading to an increased risk of fractures. Nakai, an endemic species of the Korean Peninsula, grows wild in Ulleungdo. In this study, we aimed to investigate the effects of and its components on osteoporosis.

Modeling and Simulation of Dynamic Recrystallization Microstructure Evolution for GCr15 Steel Using the Level Set Method.

The microstructure of metallic materials plays a crucial role in determining their performance. In order to accurately predict the dynamic recrystallization (DRX) behavior and microstructural evolution during the hot deformation process of GCr15 bearing steel, a microstructural evolution model for the DRX process of GCr15 steel was established by combining the level set (LS) method with the Yoshie-Laasraoui-Jonas dislocation dynamics model. Firstly, hot compression tests were conducted on GCr15 steel using the Gleeble-1500D thermal simulator, and the hardening coefficient and dynamic recovery coefficient of the Yoshie-Laasraoui-Jonas model were derived from the experimental flow stress data.

Determining ED90 of Flumazenil for Selective Respiratory Distress Improvement Using Remimazolam During Endoscopic Submucosal Dissection of Gastric Neoplasms: A Prospective Study.

Background: Patients undergoing endoscopic submucosal dissection under monitored anesthesia care (MAC) with remimazolam may develop respiratory distress during the procedure. In these cases, low doses of flumazenil improved respiratory distress without completely reversing sedation, which is a novel phenomenon. This study aimed to explore the ED90 of flumazenil to selectively improve respiratory distress in patients with MAC treated with remimazolam.

Inula japonica Thunb. and its active compounds ameliorate airway inflammation by suppressing JAK-STAT signaling.

Asthma, a chronic inflammatory disease, remains a global health challenge due to its complex pathophysiology and the limited treatment efficacy. This study explored the effect of Inula japonica Thunb. water extract (IJW) on asthma and its protective mechanisms.

Exo- and Endo-1,5-α-L-Arabinanases and Prebiotic Arabino-Oligosaccharides Production.

There is growing interest in pentose-based prebiotic oligosaccharides as alternatives to traditional hexose-based prebiotics. Among these, arabino-oligosaccharides (AOS), derived from the enzymatic hydrolysis of arabinan polymers, have gained significant attention. AOS can selectively stimulate the growth of beneficial gut bacteria, including and species, and contribute to health-benefit functions such as blood sugar control, positioning AOS as a promising synbiotic candidate.