Basket study of oral progesterone antagonist onapristone extended-release in combination with anastrozole in progesterone receptor-positive recurrent adult-type granulosa cell tumor of the ovary.

Objective: We sought to determine the safety and efficacy of the oral progesterone antagonist onapristone in combination with anastrozole in patients with recurrent progesterone receptor-positive adult-type granulosa cell tumor of the ovary.

Methods: This was a single-institution phase II study of patients with progesterone receptor-positive adult-type granulosa cell tumor who received at least 1 prior line of chemotherapy. Patients were enrolled from November 2021 to August 2022 and tissue was evaluated for progesterone receptor status via immunohistochemistry.

Concurrent Nasal Symptoms in Non-Rhinogenic Headache.

Objective: This study aims to characterize concurrent nasal symptoms in a cohort of patients with non-rhinogenic headache (NRH) presenting to an otolaryngology clinic.

Study Design: A prospective cohort.

Setting: Single tertiary care institution.

Distinct Functional Roles of Narrow and Broadband High-Gamma Activities in Human Primary Somatosensory Cortex.

Previous studies have shown that high-gamma (HG) activity in the primary visual cortex (V1) has distinct higher (broadband) and lower (narrowband) components with different functions and origins. However, it is unclear whether a similar segregation exists in the primary somatosensory cortex (S1), and the origins and roles of HG activity in S1 remain unknown. Here, we investigate the functional roles and origins of HG activity in S1 during tactile stimulation in humans and a rat model.

Real-Time Monitoring of Electrode Surface Changes in Fast-Scan Cyclic Voltammetry Using Fourier Transform Electrochemical Impedance Spectroscopy.

Fast-scan cyclic voltammetry (FSCV) is a widely used electrochemical technique to measure the phasic response of neurotransmitters in the brain. It has the advantage of reducing tissue damage to the brain due to the use of carbon fiber microelectrodes as well as having a high temporal resolution (10 Hz) sufficient to monitor neurotransmitter release in vivo. During the FSCV experiment, the surface of the carbon fiber microelectrode is inevitably changed by the fouling effect.

Awareness and care practices for rare neurologic diseases among senior neurologists: A global survey.

Objective: Rare neurologic diseases (RNDs) are difficult to diagnose and treat due to their low prevalence and complex nature. This survey evaluated awareness and current care status of RNDs among esteemed neurologists affiliated with the World Federation of Neurology (WFN).

Methods: A 34-question survey was distributed to renowned neurologists, including delegates from national neurology societies in the WFN Assembly, various WFN committees, and members of the Rare Neurologic Diseases Specialist group.